Search results for " Access"
showing 10 items of 776 documents
The cost of open access publication of papers by spanish authors in five areas of the social sciences
2021
[ES] La publicación en abierto de los artículos conlleva unos gastos conocidos como cargos por procesamiento de artículos (APC, en sus siglas en inglés). El objetivo de este trabajo es determinar el coste de los artículos publicados en abierto mediante APC de autoría española en cinco categorías temáticas de las ciencias sociales: Humanities (Multidisciplinary), Sociology, Information Science & Library Science, Education & Educational Research y Communication de la Colección Principal de la Web of Science (WoS) durante el periodo 2012-2019. Se han identificado las revistas, las instituciones financiadoras y los modelos de publicación más frecuentes. El estudio indica que de las 223 revistas…
PERSPECTIVE: Underutilized resources for studying the evolution of invasive species during their introduction, establishment, and lag phases
2010
The early phases of biological invasions are poorly understood. In particular, during the introduction, establishment, and possible lag phases, it is unclear to what extent evolution must take place for an introduced species to transition from established to expanding. In this study, we highlight three disparate data sources that can provide insights into evolutionary processes associated with invasion success: biological control organisms, horticultural introductions, and natural history collections. All three data sources potentially provide introduction dates, information about source populations, and genetic and morphological samples at different time points along the invasion trajector…
Self-validating bundles for flexible data access control
2016
Modern cloud-based services offer free or low-cost content sharing with significant advantages for the users but also new issues in privacy and security. To protect sensitive contents (i.e., copyrighted, top secret, and personal data) from the unauthorized access, sophisticated access management systems or/and decryption schemes have been proposed, generally based on trusted applications at client side. These applications work also as access controllers, verifying specific permissions and restrictions accessing user’s resources. We propose secure bundles (S-bundles), which encapsulate a behavioral model (provided as bytecode) to define versatile stand-alone access controllers and encoding/d…
Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy
2018
Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3 -AQCs)-developed by an ad hoc method-augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3 -AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3 -AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tiss…
Durvalumab after definitive chemoradiotherapy in locally advanced unresectable non-small cell lung cancer (NSCLC): Real-world data on survival and sa…
2020
Abstract Background Following the PACIFIC trial, durvalumab has been approved by the European Medicines Agency (EMA) for consolidation of locally advanced PD-L1-positive NSCLC after chemoradiotherapy (CRT). Patients were treated with durvalumab in the EAP from 22.11.2017 to 15.10.2018 allowing analysis of its efficacy and safety. Methods Data from 56 centres were analysed for adverse events (AE), progression-free survival (PFS), overall survival (OS). Results 126 patients actually received at least 1 cycle durvalumab. Compared to the PACIFIC trial, the EAP population had more advanced stage and included “oligometastatic” stage IV patients and patients with autoimmune disease. PFS (20.1 mont…
Bacterial antisense RNAs are mainly the product of transcriptional noise
2015
Most of the antisense transcripts in bacteria are the product of transcriptional noise derived from spurious promoters.
Real life experiences in HCV management in 2018
2019
Introduction: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, with approximately 71 million chronically infected individuals worldwide. Treatment of chronic hepatitis C has considerably improved in the last few years thanks to the introduction of direct-acting antivirals able to achieve sustained virological response in more than 95% of patients. Successful anti-HCV treatment can halt liver disease progression and solve the HCV-related extra-hepatic manifestations, eventually reducing liver-related and overall mortality. Areas covered: With the aim to respond to unmet needs in patient’s identification, universal access to antiviral therapy and treatment optimiza…
A Smart Contract Based Recommender System
2019
Nowadays information available on the World Wide Web has reached unprecedented growth and it makes difficult for users to find the most relevant for them. In order to alleviate such issue, Recommender Systems (RSs) have been proposed to collect opinions and preferences about a set of items, process such preferences and build a personalized information access. While the most part of current RSs exploit centralized architecture to provide the service, in this manuscript we propose an alternative approach for building a general purpose RSs that provides to users with more transparent and decentralized rating strategy. Indeed, the proposed framework is built on top of a Distributed Ledger techn…
European dominance in multistage ultramarathons: an analysis of finisher rate and performance trends from 1992 to 2010
2013
Mohannad Abou Shoak,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Romuald Lepers,3 Thomas Rosemann11Institute of General Practice and for Health Services Research, University of Zurich, Zurich, Switzerland; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: Participation and performance trends regarding the nationality of ultraendurance athletes have been investigated in the triathlon, but not in running. The present study aimed to identify the countries in which multistage ultramarathons were held around the world and the nationalities of successful finishers.Methods: Finisher rates and…
Running speed during training and percent body fat predict race time in recreational male marathoners.
2012
 Background: Recent studies have shown that personal best marathon time is a strong predictor of race time in male ultramarathoners. We aimed to determine variables predictive of marathon race time in recreational male marathoners by using the same characteristics of anthropometry and training as used for ultramarathoners.Methods: Anthropometric and training characteristics of 126 recreational male marathoners were bivariately and multivariately related to marathon race times.Results: After multivariate regression, running speed of the training units (β=-0.52, P<0.0001) and percent body fat (β=0.27, P <0.0001) were the two variables most strongly cor…